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This apparently minor modification produces a substantial functional change: the N-terminal tripeptide is the primary binding domain through which IGF-1 interacts with IGFBP-3 and IGFBP-1, the two most abundant binding proteins in circulation

doi: 10.1016/j.molmet.2022.101586

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These changes might indicate the need for dose adjustments or could signal interactions with newly started medications or supplements

Track your meals and energy levels during the first few weeks to notice patterns

A detailed structure of the peptide and c fragments is shown below the ETD data for reference