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Despite a substantial decrease in the muscle carnitine content (approximately 50%), there was no difference in spontaneous or running-wheel activities between control and cKOt mice (Supplemental Figure 7)

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In vitro co-immunoprecipitation and fluorescence polarisation assays have investigated the binding affinity of Proxofim for the p53 interaction domain, examining whether the DRI construct competitively displaces endogenous FOXO4 from the FOXO4-p53 complex in senescent fibroblast cultures

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Allicin further reduced the abundance of the structural viral proteins N, M, S and ORF3 in the host-virus proteome

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Make up two solutions of 1.051 and 1.078 g/ml by mixing Solutions A and B in the following volume ratios (1:5.8) and (1:3.5) respectively (see Note 4) 3

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