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There were rat stomach lesions in which quick exposure to mild irritants promptly conferred protection against subsequent injury from more severe irritants [43]

Therefore, the precise mechanisms through which lipoxygenases contribute to ferroptosis, particularly in GPX4 inhibition contexts, require further investigation ( 3.2.4 Therapeutic targets and experimental evidence Lipid peroxidation not only affects biological membrane fluidity and membrane protein function, impairing cellular activity, but its products also form reactive aldehyde end products, including 4-hydroxynonenal (4-HNE) and MDA

Basics and principles of cellular and systemic iron homeostasis

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doi: 10.1038/emboj.2009.101