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These combined effects lower estimated 10-year cardiovascular risk by 35-40% based on improved risk factors, though actual event reduction hasn't been proven yet

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Casson S, Jones MD, Cassar J, Kwai N, Lloyd AR, Barry BK, et al

instead, F is determined by comparing area under the curve of a plasma concentration versus time plot for an orally-administered dose with the area under the curve following an IV dose of the same amount of the same drug to the same patient