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It would happen a few hours after an injection, but only once or twice, then it would return to normal
It would be interesting to investigate whether other protein-secreting cells, like pancreatic cells producing insulin 31 or hepatocytes secreting albumin 32 , depend on PPP-generated NADPH for protein folding as well and are also susceptible to proteotoxicity in hypoxia
Ultimately, we anticipate that the continued development of precise and effective senotherapeutic interventions will lead to the targeted elimination of senescent cells, their detrimental SASP, and improved health outcomes in age-related diseases such as AD
Insulin Resistance: Chronic, high-dose use can downregulate insulin receptors, potentially leading to long-term insulin resistance and elevated fasting glucose
Also, portable nebulizers may be even more convenient in this regard