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found that 45% of East Asians have a deficiency in ALDH2 enzymatic activity, leading to ALD and increasing the risk of hepatocellular carcinoma (HCC) (Wang et al., 2021)

doi:10.1371/journal.pone.0020676, PMID: 21655192 Steullet P, Neijt HC, Cunod M, Do KQ (2006) Synaptic plasticity impairment and hypofunction of NMDA receptors induced by glutathione deficit: relevance to schizophrenia

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Short-Term Use Recommended: Typically used for 34 months, followed by a break to prevent ochronosis.