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J Photochem Photobiol B

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The combination of the lysosome disruptor siramesine and the tyrosine kinase inhibitor lapatinib increased the expression of TF and reduced the expression of FPN1 in breast cancer cells, thereby promoting iron overload in the lysosome and ultimately inducing ferroptosis ( Ferroptosis could be induced by directly supplementing the cell's active iron pool to establish an iron overload state

Supplements are also available and the usual dose is 500 to 1000 mg

Zero time values for each drug candidate were established by first treating the serum with ACN, processing the sample as described above, adding drug, and then performing HPLC analysis