Phase I detoxification uses cytochrome P450 enzymes to break down toxins, but this process often creates highly reactive, intermediate metabolites that are actually more toxic than the original substance
Champagne, J., Nielsen, M
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This auto-oxidation process generates toxic reactive oxygen species (ROS), quinones, and free radicals that damage intracellular organelles, deplete cellular glutathione, and ultimately trigger apoptotic cell death (Lohr et al., 2014
A prominent mechanism in functional GI disorders such as IBS is the modulation of the gut-brain axis