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Related studies have indicated a causal relationship between IR and all clinical symptoms of PCOS, with weight loss being shown to improve the reproductive function, hyperandrogenism and metabolism of women with PCOS (155, 156)

Contrariwise, other relevant aspects, such as the safety profile and tolerability of GLP-1RA or the beneficial effects on fertility in PCOS, have been more extensively treated, especially considering that possible direct or indirect reproductive effects of GLP-1 RA might require a concomitant effective contraception and a washout period before pregnancy [22, 24,25,26,27,28,29,30,31]

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