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Engages brainstem and hypothalamic circuits (notably in the area postrema and related nuclei) to decrease food intake, increase satiety, slow gastric emptying, and ultimately lower body weight in animal and human studies

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This is the single most common consequence of premature dosing, and it is the one that people remember

10.1016/j.ccr.2011.01.038 102 JansenR

10.1002/glia.10188