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The occurrence of hepatic stellate cells can activate hepatic stellate cells and further induce their proliferation, synthesize a large amount of cell matrix, and deposit in the extracellular space, ultimately causing liver fibrosis [40, 41]

Detailed biophysical studies (X-ray crystallography, EPR, NMR) elucidated that in GHK-Cu, the Cu(II) ion is coordinated by the imidazole side chain nitrogen of histidine, the alpha-amino nitrogen of glycine, and the deprotonated amide nitrogen of the glycine-histidine bond

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However, they are not recommended for everyone