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Why Male Fertility May Benefit from Metabolic Improvement According to a meta-analysis 1 on GLP-1 receptor agonists, such as semaglutide , found a significant rise in total testosterone (~1.39 ng/mL) and improvements in gonadotropins (LH and FSH), alongside notable weight reduction

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Intraperitoneal administration, used primarily in animal studies for convenience, results in faster absorption through the highly vascularized peritoneal membrane, shortening the dihexa half life to one to two hours and producing higher peak plasma concentrations