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The following adverse reactions have been associated with the abrupt discontinuation of the individual components of phentermine and topiramate extended-release capsules: For topiramate, abrupt discontinuation has been associated with seizures in patients without a history of seizures or epilepsy [see Warnings and Precautions (5.9)]

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For people with diabetes, additional precautions are necessary

Images were acquired using a ZEISS Axio Zoom.V16 (ZEISS, Oberkochen, Germany) stereo microscope equipped with a ZEISS PlanNeoFluar Z 1x/0.25 FWD 56 mm objective

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