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Furthermore, because of the effects of the GLP-1R agonists on caloric intake, satiety, and postprandial glucose concentrations81,82), once-weekly exenatide-treated patients experienced greater reductions in postprandial glucose concentration80)

The benefits include osmotic diuresis and natriuresis, weight loss and lipid metabolism shift, blood pressure reduction, decrease in uric acid, oxidative stress, and inflammation with a lower risk of hypoglycaemia or pancreatic -cell overstimulation

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However, it is possible that nerve cell damage will be permanent

First identified in human plasma, its concentration declines significantly with agefrom approximately 200 ng/mL in youth to 80 ng/mL by the age of 60 (Pickart and Margolina 2018)