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A randomized, double-blind, placebo-controlled trial of glutathione supplementation (500 mg/day oral) over 4 weeks documented significant reductions in melanin index at multiple body sites, with the greatest effect on sun-exposed areas (Arjinpathana & Asawanonda, 2012)

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Although early mortality was unchanged, hexarelin-treated animals showed better-preserved chronic cardiac functionhigher ejection fraction and fractional shortening and less pulmonary congestionthan vehicle-treated controls

doi:10.1007/s00449-009-0361-6 Li Z, Ye Q, Li W, Zhang S (2014) Method for producing glutathione by fermentation of recombinant Escherichia coli

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