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IgA-mediated human autoimmune hemolytic anemia as a result of hemagglutination in the spleen, but independent of complement activation and FcRI

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Likewise it is an example of hemolytic anemia due to an interaction between extra cellular and intracellular causes, since hemolysis in most cases is triggered by exogen agents 25

Temperature can also affect the final solution, as some peptides may become less stable if exposed to heat, freezing conditions, or repeated temperature changes

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