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Nutrition Research Reviews , 34 (2), 259-275.

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Giugliano D, Maiorino MI, Bellastella G, Longo M, Chiodini P, Esposito K

Before committing to long-term supplementation, clinicians should establish the underlying cause of deficiency in particular, whether pernicious anaemia is present (assessed by testing for anti-intrinsic factor antibodies and, where appropriate, anti-parietal cell antibodies), as this determines the treatment route and duration

Nevertheless, bone consequences of intentional weight loss interventions in PwO are well known: (i) significant weight loss induced by caloric restriction and bariatric surgery results in accelerated bone turnover and bone loss, and (ii) unlike caloric restriction interventions, PwO experience a substantial deterioration in bone microarchitecture and strength associated with an increased risk of fracture after bariatric surgery especially malabsorptive procedures

In preclinical research, it has been observed to influence local anabolic signaling following mechanical stress