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Cardiovasc Res 118(11):24152427 Rajili-Stojanovi M, De Vos WM (2014) The first 1000 cultured species of the human gastrointestinal microbiota

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MC4R agonism reduces ghrelin signalling and delays the gastric emptying rate, creating early satiety that lasts 48 hours

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Phase 3 trials currently underway Seven TRIUMPH trials are testing retatrutide across multiple indications: TRIUMPH-1 : Obesity without diabetes TRIUMPH-2 : Type 2 diabetes TRIUMPH-3 : Obesity with type 2 diabetes TRIUMPH-4 : Obesity with knee osteoarthritis (COMPLETED, 28.7% weight loss) TRIUMPH-5 : Obstructive sleep apnea TRIUMPH-6 and 7 : Additional indications These trials will provide the definitive data for the commercial dosage chart