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When estradiol levels rise due to fat-driven aromatization or conversion of excess external testosterone the brain senses enough sex hormone and slows down the axis: Less GnRH is released from the hypothalamus The pituitary releases less LH and FSH The testes produce less natural testosterone This negative feedback loop means men with obesity or on high-dose TRT may experience further suppression of their own testosterone production and long-term dependence on therapy

Liver Health: It is now used to treat MASH (liver scarring) caused by fatty liver disease

Self-tanners get a pretty low score (5) as they involve temporary-created and frequent applications

Cannon, MD, Contributor Disclaimer: As a service to our readers, Harvard Health Publishing provides access to our library of archived content

It reflects the chronic nature of obesity as a condition

Seek medical advice promptly for persistent gastrointestinal symptoms