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Once activated, the SMAD family member 4 (SMAD4) enters the nuclei and regulates the expression of genes inhibiting myoblast proliferation and differentiation, such as paired Box 3 (Pax3) and MyoD [120]

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For primary cell work, human skeletal muscle satellite cells, chondrocytes, and osteoblasts all express functional IGF-1R and respond robustly to IGF-1 LR3

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