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65 Guo et al

Natural semaglutide is a term often used to describe substances that mimic the effects of the synthetic hormone semaglutide

The binding of myostatin to the activin type II receptor activates Smad2/3 signaling, which suppresses protein synthesis and enhances proteolysis through activation of muscle-specific E3 ubiquitin ligases [90]

In the UK, NHS guidance lists it among the serious side effects of semaglutide and directs people to call NHS 111 if they think they may be experiencing one

Funding This work was supported by Novo Nordisk SAS, Paris

Together, they provide increasingly efficient, precise, and safe therapeutic strategies for oral cancer