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DAMPs also impact Kupffer cells, activating the nucleotide-binding oligomerization domain-like receptor (NLR) Family, Pyrin Domain-Containing 3 protein (NLRP3), a type of inflammasome leading to IL-1 secretion and inflammation, and pyroptosis, releasing more DAMPs and perpetuating a destructive cycle (Peiseler et al., 2022)

It showed about 15% weight loss in trials, with very promising results for reducing liver fat in people with fatty liver disease

The butyrate pathway is particularly relevant because it can be supported not just through probiotic supplementation but also through dietary fiber intake

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When gut bacteria ferment fibre in the colon, they produce short-chain fatty acids (SCFAs) such as butyrate, propionate, and acetate, which directly stimulate L-cells to release GLP-1

Dat betekent ook dat zogenaamde onderhoudsdosissen buiten schema, zoals 1 keer per maand spuiten in plaats van 1 keer per week, geen goed onderbouwde aanpak zijn