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Following the availability of data from these various studies, and data on c-MET expression as a biomarker that indicates a poor prognosis in patients with gastrointestinal cancer and increased c-MET expression, inhibitors targeting this pathway have entered the clinic in the past decade

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Docking studies indicate that BDNF interacts with multiple residues in the TLR4 aa 419-487 region, including L444, F463, and E439