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This section summarises research context only

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Ethyl 2- (4-ethylphenoxy) acetate (16.43g, 78.9mmol, 1.05 equiv.) and N- (thiophen-2-ylmethyl) -1H-pyrazol-5-amine (13.47g, 75.2mmol, 1 equiv., 80% to 90%) were combined in a flask under nitrogen, and sodium ethoxide (21 wt%, 2.679M ethanol solution, 30.9mL, 82.8mmol, 1.1 equiv.) was added

10.1016/j.cardiores.2004.12.027 10 Byrns ChinaN.PerlegosA

Horses, with their well-characterized pituitary anatomy and established veterinary endocrinology infrastructure, are well-positioned to serve as a large-animal validation model for these combination approaches

Not known: Frequency cannot be estimated based on the available data