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10.1016/j.bbapap.2005.08.018 84 NegreiraG
Kidney Int (2003) 64(3):93949
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A clinical trial investigating the effects of curcumin on psychological status, inflammation, and oxidative damage markers in patients with type 2 diabetes and coronary heart disease (IRCT20170513033941N63) revealed reduced malondialdehyde (MDA) levels, increased total antioxidant capacity and glutathione (GSH) levels, and upregulated PPAR- gene expression in these patients (111)
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Further studies suggested that the mechanism might involve the suppression of the TLR4/MyD88/NF-B signaling pathway by AS-IV, which downregulates the expression of downstream inflammatory cytokines such as TNF-, IL-6, and IL-8, thereby alleviating the inflammatory response induced by liver steatosis (Liu et al., 2020)
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