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Inhibited insulin signaling in mouse hepatocytes is associated with increased phosphatidic acid but not diacylglycerol

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Using hepatic puncture biopsy, Nelson et al (39) discovered that 34.5% of 849 patients with MASLD had intrahepatic iron deposition, which suggested that iron deposition was a risk factor for the progression of MASLD patients to advanced liver diseases

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Recently, we found that NRF2 regulates the serine biosynthesis pathway through ATF4 and PHGDH, which led to an independence from exogenous serine sources [43]

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5 , e201302014 (2013)

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