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While the clinical impact of GLP-1s on approved indications (e.g., obesity, diabetes, cardiovascular risk) and adjacent indications is being studied extensively in clinical trials, there is limited scientific literature on GLP-1 use, efficacy or persistence outside of clinical trial settings

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Some of these determinants are hard to crack and perhaps beyond the control of the practicing endocrinologist

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Additionally, there was a notable decrease in associated depressive states [10]

This degradation is not always visible to the naked eye, meaning a warm vial may appear normal while its active ingredient has already lost potency