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doi:10.1016/j.jand.2015.12.006

Concurrently, advances in genetics and functional genomics have strengthened causal inference by linking peptide pathways to human phenotypes through loss-of-function variants, expression quantitative trait loci, and Mendelian randomization studies

Similar compounds that could bind to GLP-1 receptors but resist inactivation by DDP-4 were researched and found to help treat type 2 diabetes mellitus (T2DM)

So if you took a drug for five years, the chances of an outcome would be five times higher than someone who took it for one year

Its not FDA-approved or recommended for this use because of the risk of serious side effects

They also act on the digestive system to delay gastric emptying, delaying the release of food from the stomach and modulating brain activity to suppress appetite