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The honest answer requires examining available evidence

Phase 2 results have been published in The New England Journal of Medicine

Published meta-analyses show berberine reduces fasting blood glucose by roughly 1015 mg/dL and HbA1c by 0.50.6% in people with type 2 diabetes or metabolic syndrome (Liang et al., 2019

Carry a water bottle, sip regularly, and include fluids that replace electrolytes if you have persistent nausea or diarrhea

Although there are data in animal models supporting that this is true, particularly in diet-induced obese mice, in which brown adipose tissue activity is regulated [8], there is no convincing evidence that this occurs in humans [6]

Thiazolidinedione Induced Thyroid Associated Orbitopathy