For instance, while most GLP-1 medications are typically prescribed for treating type 2 diabetes, semaglutide and tirzepatide can be safely used by anyone (regardless of diabetes status) for significant weight loss
PMID: 24245943
Preclinical animal studies raise concerns about reproductive toxicity, whereas emerging human data suggest no significant increase in major congenital malformations compared with insulin
Therefore, proceed with caution regarding any GLP-1 enhancing supplements
The most commonly reported adverse events in Phase 2 and Phase 3 trials were gastrointestinal in nature, including nausea, diarrhea, vomiting, and constipation
People were matched on factors including age, sex, race, BMI, and diabetes status to create comparable groups of GLP-1 users and nonusers