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Clinical Evidence on GLP-1 and GIP Receptor Agonists Semaglutide (GLP-1 agonist) achieves approximately 1015% mean body weight reduction in clinical trials, with individual outcomes ranging from minimal to 20%+ loss

Patients using ongoing oral contraceptives alongside tirzepatide should follow manufacturer guidance regarding backup contraception during initiation and dose escalation periods to ensure reliable pregnancy prevention

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They also wanted to know if patients who tapered off semaglutide, by slowly reducing their dose to zero, regained weight after coming off it completely

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