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These include inhibiting the JAK2STAT3 signaling pathway, reducing GFAP expression, blocking inflammatory pathways such as NF-B, regulating neurotransmitter secretion such as GABA and modulating APOE expression to control astrogliosis 81,137,138

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Table 1 Summary of the clinical trials reported in this study

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Lean-XT is stimulant free and can be stacked with thermogenic fat-burners, like Burn-XT