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While we have shown that UNC10088 and related analogs can engage both NSD2 and FBXO22 independently in a bivalent manner, the observed cooperative binding likely contributes to the potency of NSD2 degradation

The 1 mg arm of Phase 2 produced direct measurement

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Last month (May 2025), Novo announced that the US Food and Drug Administration (FDA) accepted its new drug application (NDA) submission for an investigational once-daily oral formulation of Wegovy (semaglutide) for chronic weight management in adults living with obesity or overweight with one or more comorbid conditions and to reduce the risk of major adverse cardiovascular events in adults with overweight or obesity and established cardiovascular disease

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