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In a long-term evaluation of the LEADER trial with 9,340 patients with T2D over a 3.5- to 5-year period, there was no evidence of C-cell malignancies occurred in the liraglutide group [84]

Some patients develop injection site reactions, bruising, or discomfort

Female gender, high pre-prophylaxis attack frequency, predominant abdominal attacks and Berotralstat treatment were associated with resistance to prophylaxis

This peptide was isolated in Zurich by Rinderknecht and Humbel on the basis of its insulin-like activity, but was renamed IGF-1 when it became apparent that its growth-promoting properties were more important than their insulin-like activities (Rinderknecht & Humbel, 1978)