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GLP-1 exerts its action through the GLP-1 receptor (GLP-1R) 4 expressed in the pancreas, other peripheral tissues, and the central nervous system

In the PIONEER clinical trials, once-daily oral semaglutide demonstrated better efficacy compared to placebo, sitagliptin, empagliflozin, liraglutide, and dulaglutide in reducing cardiovascular risk [12]

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This information may help explain why consistent dosing is critical for your specific physiology and reinforce the importance of planning ahead to avoid missed doses

Results suggest that dosing patterns were heterogeneous over time and depended on GLP-1 RA type

A deficiency is characterised by megaloblastic anaemia, fatigue, weakness, constipation, loss of appetite, and weight loss