Some individuals report feeling lightheaded or experiencing headaches after taking large doses of B12
American Association of Clinical Endocrinologists and American College of Endocrinology guidelines for management of dyslipidemia and prevention of cardiovascular disease
Lancet Psychiatry 6 , 675712 (2019)
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Rare but serious side effects that require urgent medical attention include acute pancreatitis (severe, persistent abdominal pain, sometimes with vomiting) and gallbladder disease (right upper quadrant pain, fever, jaundice)
Thats why so many people on semaglutide or tirzepatide end up with a crowded counter: protein powder, a multivitamin, a fiber supplement, electrolytes, digestive enzymes, a probiotic often 10+ pills and powders a day, at $5.40 or more per day