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Lipohypertrophy, a condition resembling lipedema in its fat distribution, differs in the lack of associated pain, edema, or hematoma tendency.8 Chronic venous insufficiency may present with limb swelling, varicosities, and hyperpigmentation, but these features typically improve with rest and elevation, unlike in lipedema.30 Advanced imaging techniques such as duplex ultrasound, lymphoscintigraphy, Magnetic Resonance Imaging (MRI), and Computed Tomography (CT) can assist in the diagnostic process by revealing distinct patterns of tissue involvement and venous or lymphatic function
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IOC is a leading cause of mortality in individuals with chronic anemia-related disorders, such as -thalassemia and SCD, who undergo long-term transfusions, affecting approximately 2.5% of chronically transfusion-dependent SCD patients [19, 36, 41]
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