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Insulitis is classified as 15 CD45+ cells per islet in a minimum of three islets ( In humans, roughly 20-30% of insulin-containing islets have been shown to exhibit insulitis compared to 2.9% in insulin-deficient islets ( 3 The genetic landscape of T1D: from risk scores to functional pathways Predisposition to T1D is caused by genetic susceptibility in multiple loci, including INS , IFIH1 , and the class I and II HLA genes (57)