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Benito J, Hongbo L, Wilson WR, Melink TJ, Feliu J, Konoplev S, Estey E, Kantarjian H, Gutheil JC, Andreeff M , Konopleva M

Thus, sertraline interferes with the function of the hypothalamicpituitarytesticular and hypothalamicpituitaryadrenal axes by affecting the wide distribution of serotonin receptors, thereby leading to reduced fertility in male rats (Figure 3)

J Pharmacol Exp Ther 2006;317:11061113

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Similar to succinate, fumarate contributes to the inactivation of PHD, stabilizing HIF proteins to promote cell survival 133 (Fig