Patients with severe kidney disease (eGFR below 2030) Patients with recurrent UTIs or fungal infections Type 1 diabetes patients (unless specifically prescribed) Pregnant women References: Protective Influence of SGLT-2 Inhibitors Against Heart Failure PMC 2024 Clinical Evidence for Cardiovascular & Kidney Benefits PMC SGLT2 Inhibitors: Antidiabetic and Cardioprotective Effects PMC Emerging Horizons: SGLT-2 Inhibitors Beyond Diabetes PMC DPP-4 inhibitors, sulfonylureas, TZDs So far we have covered the star players Metformin, GLP-1 agonists, and SGLT2 inhibitors
Robbins, R
This can lead to fatigue, immune weakness, brain fog, and slower recovery from illness or exertion
Dubey S, Shri M, Misra P, Lakhwani D, Bag SK, Asif MH, Trivedi PK, Tripathi RD, Chakrabarty D
J Clin Invest 99 : 25382544 Ranke MB (2005) Insulin-like growth factor-I treatment of growth disorders, diabetes mellitus and insulin resistance
By weeks 5-8, when appetite suppression reaches stronger levels, weekly weight loss often increases to 1-2 pounds per week, with some individuals experiencing faster initial losses
