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Its about the cause of the deficiency, what the patient prefers, and how well they absorb it
Not effective for individuals with severe deficiencies
Due to the compounds plasma half-life of approximately 3.86.9 hours [4] , twice-daily (BID) dosing may provide more sustained NNMT inhibition
The even better news: side effects from vitamin B12 supplements are usually mild, says Richard Foxx, M.D., a board-certified physician who treats hormonal disorders and nutritional deficiencies
Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent