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While in use, they saturate those receptorsparticularly in the brain and stomachmimicking the effects of endogenous GLP-1 at sky-high, sustained levels

Escalation trigger: Any worsening nausea, black or tarry stools, or drop in urine output warrants same-day contact with the prescribing provider

Wegovy is FDA-approved to reduce cardiovascular events in patients with heart disease and obesity

The ceiling for cognitive benefit appears around 8001000 mcg for most individuals

Although the primary motor outcome was neutral, the study confirmed safety and hinted at benefits in secondary domains, solidifying GLP-1 RAs as a viable therapeutic avenue