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Al-Aly pointed directly to the ability of GLP-1s to act on receptors in the brain to explain these effects

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Seek medical advice if nausea persists for more than a few days and interferes with eating or drinking, if you experience repeated vomiting preventing fluid retention, or if you develop signs of dehydration such as reduced urine output, dizziness, or confusion

These obstacles exist despite broad recognition of GLP-1 efficacy

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