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Think of each receptor as a separate metabolic lever

Jastreboff AM, et al

-Dose response, GI tolerance, Adherence, and outcomes across different dietary patterns and BMI phenotypes will matter more than headline percentages

Septerna Sector: GPC Septerna R-targeted oral small molecule drug discovery, including GLP-1, GIP, and glucagon receptors HQ: South San Francisco, CA Year Founded: 2019 (under the name GPCR NewCo, Inc.)

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Medicare will begin covering GLP-1 medications for obesity through the Medicare GLP-1 Bridge program starting July 1, 2026, offering eligible beneficiaries access for $50 per month