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3.2 Second-generation long-acting analogs The evolution developed with the emergence of second-generation GLP-1 receptor agonists, suggesting a notable advancement in molecular design and clinical application

Our research revealed that our proposed quantitative parameters correlated with metabolic factors in NAFLD

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Importantly, GLP-1RAs do not exert direct immunosuppressive effects but instead modulate inflammatory pathways indirectly through metabolic and cellular mechanisms, supporting a favourable safety profile when used alongside bDMARDs

The second pathway for homocysteine is to undergo remethylation to form methionine (FIG

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