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If the presence of an initial stressor is prolonged, the HPA axis will become chronically activated and trigger the overproduction of cortisol which, over time, will result in a reduction in cortisol levels (427)

It is unique because it works at a cellular level and is present in every cell

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The mechanisms involved, gene expression modulation, collagen synthesis, tissue remodeling, operate on timescales of weeks to months

After graduating medical school from the University of Hawaii, he completed residency training in Occupational and Environmental Medicine from the University of Utah where he also earned a master's degree in Occupation Health