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Table of Contents How DPP-4 Inhibitors Work to Reduce Blood Sugar Levels Expected HbA1c Reductions With DPP-4 Inhibitor Treatment Comparing DPP-4 Inhibitors to Other Type 2 Diabetes Medicines NICE Guidelines on Using DPP-4 Inhibitors in Type 2 Diabetes Factors That Affect How Well DPP-4 Inhibitors Lower HbA1c Side Effects and Safety Considerations for Patients Scientific References Frequently Asked Questions How DPP-4 Inhibitors Work to Reduce Blood Sugar Levels DPP-4 inhibitors block the enzyme that degrades incretin hormones GLP-1 and GIP, increasing insulin secretion and reducing glucagon release in a glucose-dependent manner, which limits hypoglycaemia risk when used alone or with metformin

This protective effect is mainly advantageous for type 2 diabetes, where beta cells are still present but not functioning well

Methionine S-adenosyl-methionine (SAM-e) is a supplement that contains methionine and can also help boost glutathione levels

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