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65 , e12503 (2018)
We hypothesize that the failure of intrinsic-solubility approaches arises from inaccuracies in the predicted valuesalthough Starling is a state-of-the-art p K a -prediction model, it still routinely predicts values that are wrong by 0.51.0 p K a unit, which can correspond to a 10x difference in the predicted value
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Moreover, hesperetin and hesperidin are reported to directly suppress viral replication in other pathogens such as RSV, zika virus (ZIKV), chikungunya virus (CHIKV), suggesting them as potential broad-spectrum antiviral agents with multi-target mechanisms (302, 303)
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