The GLP-1R and GIPR components reduce ectopic hepatic fat delivery (by reducing adipose lipolysis and improving insulin signaling), while the GCGR component simultaneously increases the livers capacity to clear the fat that does arrive
By enhancing fatty acid oxidation, it reduces the need for the body to catabolize amino acids for energy
On the materials and delivery front, recent reviews and studies of PLGA nanomedicines highlight robust strategies for mucosal delivery, barrier crossing, and integration of diagnostics with targeted payload release
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