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Evidence points to the 2-hydroxyestrone metabolite as perhaps the safest estrogen metabolite, so it earns the label of good estrogen, although it is not without potential problems

In humans, increased plasma concentrations have not been conclusively associated with an increase in the skeletal muscle carnitine pool [23]

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Furthermore, this study reported that mice exposed to three days of dLAN post MCAO increased TNF-, IL-6, and IL-1 in the ipsilateral hemisphere of the brain, and displayed increased anxiety-like behavior compared to control mice (Weil et al., 2020)

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